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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) greater than 27, provided they also experience weight-related health problems such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment choice for chronic weight management for people who are obese or are overweight and still have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes indicated that patients had an average weight loss of four years old.1% as opposed to participants who have been given placebos) during a 12- month period, while a different study involving patients with diabetes had an average weight loss of 2% over treatment with placebo at twelve months.
Using two separate drugs to lose weight naturally can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it you ought to err along the side of caution and permit the FDA do its job and demand some study be done in order that the public is aware of the side effects and risks of the medications before we bring them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on their own medications.
Researchers found that participants using this drug to get a year, lost weight within one month and have kept the body weight off during the entire 56 weeks in the study. Contrave can be a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs that are made up of many active ingredient, which may make them more potent and safer.
Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and so it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is becoming popular could be the fact that as of right now there aren't long term prescription slimming capsules that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be licensed by the FDA.
Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise blood pressure levels and heartbeat, and really should not be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.
The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not be used in patients with uncontrolled high blood pressure level, as well as by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients which has a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.
The most common side effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.