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  • The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) greater than 27, provided that they also experience weight-related health concerns such as Tupe2 diabestes, high cholesterol and/or hypertension (hypertension).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie eating and working out, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and possess at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes established that patients had an average weight loss of four years old.1% in contrast to participants have been given placebos) after a 12- month period, while an outside study involving patients with diabetes type 2 had the average weight loss of 2% over treatment with placebo at 12 months.

    Using two separate drugs to lose weight naturally can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err along the side of caution and allow the FDA do its job and demand some study be done in order that the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies have been in business to generate income and that they would say anything to keep people on the medications.

    Researchers found that participants investing in this drug for any year, lost excess weight within one month and have kept the load off through the entire 56 weeks from the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which might be made up of more than one active ingredient, which can make them more effective and safer.

    Combo-pilling is the newest fad or even better the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills is now popular could be the fact that at the time of right now there aren't any long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug can also raise blood pressure levels and heartrate, and shouldn't be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure and heartrate and must not be used in patients with uncontrolled high blood pressure levels, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients for the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.