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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) greater than 27, given that they also have problems with weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder and as an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that features a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of 4.1% in contrast to participants who were given placebos) after a 12- month period, while an outside study involving patients with diabetes type 2 symptoms had a typical weight loss of 2% over treatment with placebo at one year.
Using two separate drugs to lose weight naturally can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err assisting caution and allow FDA do its job and demand some investigation be done so the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to make money and that they would say almost anything to keep people on the medications.
Researchers found that participants taking this drug to get a year, lost weight within 4 weeks and have kept the extra weight off through the 56 weeks with the study. Contrave can be a combination from the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them more efficient and safer.
Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that by right now there are not any long term prescription weightloss pills that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA.
Seizures can be a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure levels and pulse rate, and shouldn't be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.
The FDA also warned that Contrave can raise blood pressure and heartrate and must not used in patients with uncontrolled high blood pressure levels, and also by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.
Other people who should avoid using Contrave are patients suffering from bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave really should not be prescribed for ladies who are pregnant or attempting to become pregnant.