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It was discovered that naltrexone and bupropion combined, that could be marketed in the future as Contrave, have better weight loss results than eating and working out alone.
Using two separate drugs to shed weight can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you need to err on the side of caution and permit the FDA do its job and demand some research be done so the public is aware of the side effects and risks of the medications before we take them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on the medications.
Researchers found out that participants investing in this drug for the year, lost weight within a month and have kept the extra weight off throughout the 56 weeks of the study. Contrave is a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them more efficient and safer.
Combo-pilling will be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that by right now there are not any long term prescription weight loss supplements that have been authorized by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA.
Seizures certainly are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug also can raise blood pressure level and heart rate, and really should not be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.
The FDA also warned that Contrave can raise blood pressure levels and heartrate and must stop used in patients with uncontrolled high blood pressure, in addition to by a person with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients for the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.
"There were no signs of depression or suicidal thoughts in trial participants," said Fujioka.