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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) greater than 27, so long as they also are afflicted by weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so that as an aid to smoking cessation treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of 4.1% instead of participants who were given placebos) throughout a 12- month period, while a different study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to shed pounds can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people that go through it you should err assisting caution and allow FDA do its job and demand some research be done so your public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on the medications.

    Researchers discovered that participants using this drug for a year, lost weight within a month and have kept the extra weight off through the 56 weeks in the study. Contrave is really a combination with the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which are made up of several active ingredient, which may make them more potent and safer.

    Combo-pilling will be the newest fad or also the newest to come under scrutiny and thus it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular may be the fact that as of right now there aren't long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug also can raise blood pressure levels and heart rate, and mustn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must 't be used in patients with uncontrolled high blood pressure, as well as by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients for the increased risk of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking.

    Other people who should avoid using Contrave are patients suffering from bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave shouldn't be prescribed for females who are pregnant or trying to become pregnant.