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Evidence is increasing that every addiction without exception is related to difficulty with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err on the side of caution and allow the FDA do its job and demand some study be done in order that the public knows the side effects and dangers of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on their own medications.
Researchers discovered that participants using this drug for any year, dropped a few pounds within a month and have kept the weight off through the 56 weeks from the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which can be made up of several active ingredient, that might make them more potent and safer.
Combo-pilling may be the newest fad or even better the newest into the future under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that as of right now there aren't any long term prescription weightloss pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA.
Seizures really are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise hypertension and heart rate, and really should not be used in individuals with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.
The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not used in patients with uncontrolled high blood pressure, in addition to by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking.
From a psychiatric viewpoint, evidence points too the ordinary neural mechanism for goal-directed behavior has become hijacked by the addiction, and malfunctions such that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus along with the person engages in a "goal-directed behavioral response" that produces a "natural high"(Bostwick & Bucci, 2008).